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Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin
Huntington disease (HD) is a neurodegenerative disorder caused by a CAG expansion within the huntingtin gene that encodes a polymorphic glutamine tract at the amino terminus of the huntingtin protein. HD is one of nine polyglutamine expansion diseases. The clinical threshold of polyglutamine expansi...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3767516/ https://ncbi.nlm.nih.gov/pubmed/23898200 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301342110 |
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