Spray Drying Tenofovir Loaded Mucoadhesive and pH-Sensitive Microspheres Intended for HIV Prevention

PURPOSE: To develop spray dried mucoadhesive and pH-sensitive microspheres (MS) based on polymethacrylate salt intended for vaginal delivery of tenofovir (a model HIV microbicide) and assess their critical biological responses. METHODS: The formulation variables and process parameters are screened a...

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Main Authors: Zhang, Tao, Zhang, Chi, Agrahari, Vivek, Murowchick, James B., Oyler, Nathan A., Youan, Bi-Botti C.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767469/
https://ncbi.nlm.nih.gov/pubmed/23274788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2012.12.019
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