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Comparative biophysical properties of tenofovir-loaded, thiolated and nonthiolated chitosan nanoparticles intended for HIV prevention

AIM: This study is designed to test the hypothesis that tenofovir-loaded (an anti-HIV microbicide) chitosan–thioglycolic acid-conjugated (CS–TGA) nanoparticles (NPs) exhibit superior biophysical properties for mucoadhesion compared with those of native CS NPs. MATERIALS & METHODS: The NPs are pr...

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Dettagli Bibliografici
Pubblicato in:Nanomedicine (Lond)
Autori principali: Meng, Jianing, Zhang, Tao, Agrahari, Vivek, Ezoulin, Miezan J, Youan, Bi-Botti C
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4278848/
https://ncbi.nlm.nih.gov/pubmed/24405490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/nnm.13.136
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