Thermodynamic Characterization of Five Key Kinetic Parameters that Define Neuronal Nitric Oxide Synthase Catalysis

NO synthase (NOS) enzymes convert L-arginine to NO in two sequential reactions whose rates (k(cat1) and k(cat2)) are both limited by the rate of ferric heme reduction (k(r)). An enzyme ferric heme-NO complex forms as an immediate product complex and then undergoes either dissociation (at a rate that...

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Main Authors: Haque, Mohammad Mahfuzul, Tejero, Jesús, Bayachou, Mekki, Wang, Zhi-Qiang, Fadlalla, Mohammed, Stuehr, Dennis J.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767175/
https://ncbi.nlm.nih.gov/pubmed/23789902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.12404
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