Notch1 induced brain tumor models the sonic hedgehog subgroup of human medulloblastoma

While activation of the Notch pathway is observed in many human cancers, it is unknown whether elevated Notch1 expression is sufficient to initiate tumorigenesis in most tissues. To test the oncogenic potential of Notch1 in solid tumors, we expressed an activated form of NOTCH1 (N1ICD) in the develo...

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Bibliographic Details
Main Authors:	Natarajan, S., Li, Y., Miller, E.E., Shih, D. J, Taylor, M. D., Stearns, T. M., Bronson, R. T., Ackerman, S. L., Yoon, J., Yun, K.
Format:	Artigo
Language:	Inglês
Published:	2013
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3766480/ https://ncbi.nlm.nih.gov/pubmed/23852537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-0033
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Notch1 induced brain tumor models the sonic hedgehog subgroup of human medulloblastoma

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