ATOH1 promotes leptomeningeal dissemination and metastasis of Sonic Hedgehog subgroup medulloblastomas

Medulloblastoma (MB) arising from the cerebellum is the most common pediatric brain malignancy, with leptomeningeal metastases often present at diagnosis and recurrence associated with poor clinical outcome. In this study, we employed mouse MB models to explore the relationship of tumor pathophysiol...

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Publicat a:Cancer Res
Autors principals: Grausam, Katie B., Dooyema, Samuel D. R., Bihannic, Laure, Premathilake, Hasitha, Morrissy, A. Sorana, Forget, Antoine, Schaefer, Amanda M., Gundelach, Justin H., Macura, Slobodan, Maher, Diane M., Wang, Kevin, Heglin, Alex H., Ge, Xijin, Zeng, Erliang, Puget, Stephanie, Chandrasekar, Indra, Surendran, Kameswaran, Bram, Richard J., Schüller, Ulrich, Talyor, Michael D., Ayrault, Olivier, Zhao, Haotian
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512702/
https://ncbi.nlm.nih.gov/pubmed/28490517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-1836
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