WERNER SYNDROME HELICASE HAS A CRITICAL ROLE IN DNA DAMAGE RESPONSES IN THE ABSENCE OF A FUNCTIONAL FANCONI ANEMIA PATHWAY

Werner syndrome (WS) is genetically linked to mutations in WRN that encodes a DNA helicase-nuclease believed to operate at stalled replication forks. Using a newly identified small molecule inhibitor of WRN helicase (NSC 617145), we investigated the role of WRN in the interstrand cross-link (ICL) re...

Full description

Saved in:

Bibliographic Details
Main Authors:	Aggarwal, Monika, Banerjee, Taraswi, Sommers, Joshua A., Iannascoli, Chiara, Pichierri, Pietro, Shoemaker, Robert H., Brosh, Robert M.
Format:	Artigo
Language:	Inglês
Published:	2013
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3766423/ https://ncbi.nlm.nih.gov/pubmed/23867477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-2975
Tags:	Add Tag No Tags, Be the first to tag this record!

WERNER SYNDROME HELICASE HAS A CRITICAL ROLE IN DNA DAMAGE RESPONSES IN THE ABSENCE OF A FUNCTIONAL FANCONI ANEMIA PATHWAY

Similar Items