WERNER SYNDROME HELICASE HAS A CRITICAL ROLE IN DNA DAMAGE RESPONSES IN THE ABSENCE OF A FUNCTIONAL FANCONI ANEMIA PATHWAY

Werner syndrome (WS) is genetically linked to mutations in WRN that encodes a DNA helicase-nuclease believed to operate at stalled replication forks. Using a newly identified small molecule inhibitor of WRN helicase (NSC 617145), we investigated the role of WRN in the interstrand cross-link (ICL) re...

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Detaylı Bibliyografya
Asıl Yazarlar: Aggarwal, Monika, Banerjee, Taraswi, Sommers, Joshua A., Iannascoli, Chiara, Pichierri, Pietro, Shoemaker, Robert H., Brosh, Robert M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3766423/
https://ncbi.nlm.nih.gov/pubmed/23867477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-2975
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