Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval

Variability in response to drug use is common and heritable, suggesting that genome-wide pharmacogenomics studies may help explain the “missing heritability” of complex traits. Here, we describe four independent analyses in 33,781 participants of European ancestry from ten cohorts that were designed...

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Main Authors: Avery, Christy L., Sitlani, Colleen M., Arking, Dan E., Arnett, Donna K., Bis, Joshua C., Boerwinkle, Eric, Buckley, Brendan M., Chen, Y.-D. Ida, de Craen, Anton JM, Eijgelsheim, Mark, Enquobahrie, Daniel, Evans, Daniel S., Ford, Ian, Garcia, Melissa E., Gudnason, Vilmundur, Harris, Tamara B., Heckbert, Susan R., Hochner, Hagit, Hofman, Albert, Hsueh, Wen-Chi, Isaacs, Aaron, Jukema, J. Wouter, Knekt, Paul, Kors, Jan A., Krijthe, Bouwe P., Kristiansson, Kati, Laaksonen, Maarit, Liu, Yongmei, Li, Xiaohui, MacFarlane, Peter W., Newton-Cheh, Christopher, Nieminen, Markku S., Oostra, Ben A., Peloso, Gina M., Porthan, Kimmo, Rice, Kenneth, Rivadeneira, Fernando F., Rotter, Jerome I., Salomaa, Veikko, Sattar, Naveed, Siscovick, David S., Slagboom, P. Eline, Smith, Albert V., Sotoodehnia, Nona, Stott, David J., Stricker, Bruno H., Stürmer, Til, Trompet, Stella, Uitterlinden, Andre G., van Duijn, Cornelia M., Westendorp, Rudi GJ, Witteman, Jacqueline C., Whitsel, Eric A., Psaty, Bruce M.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2013
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3766418/
https://ncbi.nlm.nih.gov/pubmed/23459443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2013.4
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