Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele

BACKGROUND: Numerous clinical trials in stroke have failed, most probably partially due to preclinical studies using young, healthy male rodents with little relevance to the heterogenic conditions of human stroke. Co-morbid conditions such as atherosclerosis and infections coupled with advanced age...

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Detalhes bibliográficos
Main Authors: Dhungana, Hiramani, Rolova, Taisia, Savchenko, Ekaterina, Wojciechowski, Sara, Savolainen, Kaisa, Ruotsalainen, Anna-Kaisa, Sullivan, Patrick M, Koistinaho, Jari, Malm, Tarja
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3765906/
https://ncbi.nlm.nih.gov/pubmed/23957944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-10-102
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