Identification of novel PTPRQ phosphatase inhibitors based on the virtual screening with docking simulations

Protein tyrosine phosphatase receptor type Q (PTPRQ) is an unusual PTP that has intrinsic dephosphorylating activity for various phosphatidyl inositides instead of phospho-tyrosine substrates. Although PTPRQ was known to be involved in the pathogenesis of obesity, no small-molecule inhibitor has bee...

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Autores principales: Park, Hwangseo, Yu, Keum Ran, Ku, Bonsu, Kim, Bo Yeon, Kim, Seung Jun
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3765866/
https://ncbi.nlm.nih.gov/pubmed/23981594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4682-10-49
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