A multiple-alignment based primer design algorithm for genetically highly variable DNA targets

BACKGROUND: Primer design for highly variable DNA sequences is difficult, and experimental success requires attention to many interacting constraints. The advent of next-generation sequencing methods allows the investigation of rare variants otherwise hidden deep in large populations, but requires a...

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Main Authors: Brodin, Johanna, Krishnamoorthy, Mohan, Athreya, Gayathri, Fischer, Will, Hraber, Peter, Gleasner, Cheryl, Green, Lance, Korber, Bette, Leitner, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
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Software
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3765731/
https://ncbi.nlm.nih.gov/pubmed/23965160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-14-255
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