Nitric oxide modulates the hyperalgesic response to mechanical noxious stimuli in sleep-deprived rats

BACKGROUND: Sleep restriction alters pain perception in animals and humans, and many studies have indicated that paradoxical sleep deprivation (PSD) promotes hyperalgesia. The hyperalgesia observed after mechanical nociceptive stimulus is reversed through nitric oxide synthase (NOS) inhibition. Both...

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Main Authors: Damasceno, Fabio, Skinner, Gabriela O, Araújo, Paulo C, Ferraz, Marcia MD, Tenório, Frank, de Almeida, Olga MMS
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3765713/
https://ncbi.nlm.nih.gov/pubmed/23987566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-14-92
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