Crystal Structure of 3-Hydroxybenzoate 6-Hydroxylase Uncovers Lipid-assisted Flavoprotein Strategy for Regioselective Aromatic Hydroxylation

3-Hydroxybenzoate 6-hydroxylase (3HB6H) from Rhodococcus jostii RHA1 is a dimeric flavoprotein that catalyzes the NADH- and oxygen-dependent para-hydroxylation of 3-hydroxybenzoate to 2,5-dihydroxybenzoate. In this study, we report the crystal structure of 3HB6H as expressed in Escherichia coli. The...

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Asıl Yazarlar: Montersino, Stefania, Orru, Roberto, Barendregt, Arjan, Westphal, Adrie H., van Duijn, Esther, Mattevi, Andrea, van Berkel, Willem J. H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2013
Konular:
Enzymology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764827/
https://ncbi.nlm.nih.gov/pubmed/23864660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.479303
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