Actin Dynamics Regulated by the Balance of Neuronal Wiskott-Aldrich Syndrome Protein (N-WASP) and Cofilin Activities Determines the Biphasic Response of Glucose-induced Insulin Secretion

Actin dynamics in pancreatic β-cells is involved in insulin secretion. However, the molecular mechanisms of the regulation of actin dynamics by intracellular signals in pancreatic β-cells and its role in phasic insulin secretion are largely unknown. In this study, we elucidate the regulation of acti...

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Detalhes bibliográficos
Main Authors: Uenishi, Eita, Shibasaki, Tadao, Takahashi, Harumi, Seki, Chihiro, Hamaguchi, Hitomi, Yasuda, Takao, Tatebe, Masao, Oiso, Yutaka, Takenawa, Tadaomi, Seino, Susumu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764791/
https://ncbi.nlm.nih.gov/pubmed/23867458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.464420
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