A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells

Mast cells coordinate allergy and allergic asthma and are crucial cellular targets in therapeutic approaches to inflammatory disease. Allergens cross-link IgE bound at high-affinity receptors on the mast cell's surface, causing release of pre-formed cytoplasmic granules containing inflammatory...

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Hlavní autoři: Staser, Karl, Shew, Matthew A, Michels, Elizabeth G, Mwanthi, Muithi M, Yang, Feng-Chun, Clapp, D Wade, Park, Su-Jung
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764489/
https://ncbi.nlm.nih.gov/pubmed/23063725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2012.10.001
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