Hsp104 Suppresses Polyglutamine-Induced Degeneration Post Onset in a Drosophila MJD/SCA3 Model

There are no effective therapeutics that antagonize or reverse the protein-misfolding events underpinning polyglutamine (PolyQ) disorders, including Spinocerebellar Ataxia Type-3 (SCA3). Here, we augment the proteostasis network of Drosophila SCA3 models with Hsp104, a powerful protein disaggregase...

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Detaylı Bibliyografya
Asıl Yazarlar: Cushman-Nick, Mimi, Bonini, Nancy M., Shorter, James
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764203/
https://ncbi.nlm.nih.gov/pubmed/24039611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003781
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