Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells

HIV-infected individuals currently cannot be completely cured because existing antiviral therapy regimens do not address HIV provirus DNA, flanked by long terminal repeats (LTRs), already integrated into host genome. Here, we present a possible alternative therapeutic approach to specifically and di...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Qu, Xiying, Wang, Pengfei, Ding, Donglin, Li, Lin, Wang, Haibo, Ma, Li, Zhou, Xin, Liu, Shaohui, Lin, Shiguan, Wang, Xiaohui, Zhang, Gongmin, Liu, Sijie, Liu, Lin, Wang, Jianhua, Zhang, Feng, Lu, Daru, Zhu, Huanzhang
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2013
Aiheet:
Molecular Biology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3763554/
https://ncbi.nlm.nih.gov/pubmed/23804764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt571
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