Nuclear CaMKII enhances histone H3 phosphorylation and remodels chromatin during cardiac hypertrophy

Calcium/calmodulin-dependent protein kinase II (CaMKII) plays a central role in pathological cardiac hypertrophy, but the mechanisms by which it modulates gene activity in the nucleus to mediate hypertrophic signaling remain unclear. Here, we report that nuclear CaMKII activates cardiac transcriptio...

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Detalhes bibliográficos
Main Authors: Awad, Salma, Kunhi, Muhammad, Little, Gillian H., Bai, Yan, An, Woojin, Bers, Donald, Kedes, Larry, Poizat, Coralie
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Gene Regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3763528/
https://ncbi.nlm.nih.gov/pubmed/23804765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt500
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