Nuclear CaMKII enhances histone H3 phosphorylation and remodels chromatin during cardiac hypertrophy

Calcium/calmodulin-dependent protein kinase II (CaMKII) plays a central role in pathological cardiac hypertrophy, but the mechanisms by which it modulates gene activity in the nucleus to mediate hypertrophic signaling remain unclear. Here, we report that nuclear CaMKII activates cardiac transcriptio...

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Bibliographische Detailangaben
Hauptverfasser: Awad, Salma, Kunhi, Muhammad, Little, Gillian H., Bai, Yan, An, Woojin, Bers, Donald, Kedes, Larry, Poizat, Coralie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2013
Schlagworte:
Gene Regulation, Chromatin and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3763528/
https://ncbi.nlm.nih.gov/pubmed/23804765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt500
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