Architecture and DNA Recognition Elements of the Fanconi Anemia FANCM-FAAP24 Complex

Fanconi anemia (FA) is a disorder associated with a failure in DNA repair. FANCM (defective in FA complementation group M) and its partner FAAP24 target other FA proteins to sites of DNA damage. FANCM-FAAP24 is related to XPF/MUS81 endonucleases but lacks endonucleolytic activity. We report a struct...

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Autores principales: Coulthard, Rachel, Deans, Andrew J., Swuec, Paolo, Bowles, Maureen, Costa, Alessandro, West, Stephen C., McDonald, Neil Q.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cell Press 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3763369/
https://ncbi.nlm.nih.gov/pubmed/23932590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.07.006
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