A Novel Bayesian Seamless Phase I/II Design

This paper proposes a novel bayesian phase I/II design featuring using a hybrid mTPI method in phase I for targeting the MTD level and a randomization allocation schema for adaptively assigning patients to desirable doses in phase II. The mechanism of simultaneously escalating dose in phase I and ex...

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Detaylı Bibliyografya
Asıl Yazarlar: Pan, Haitao, Huang, Ping, Wang, Zuoren, Wang, Ling, Li, Chanjuan, Xia, Jielai
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3762894/
https://ncbi.nlm.nih.gov/pubmed/24023809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073060
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