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A Novel Bayesian Seamless Phase I/II Design
This paper proposes a novel bayesian phase I/II design featuring using a hybrid mTPI method in phase I for targeting the MTD level and a randomization allocation schema for adaptively assigning patients to desirable doses in phase II. The mechanism of simultaneously escalating dose in phase I and ex...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3762894/ https://ncbi.nlm.nih.gov/pubmed/24023809 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073060 |
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