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mRNA surveillance and endoplasmic reticulum quality control processes alter biogenesis of mutant GABA(A) receptor subunits associated with genetic epilepsies
Previous studies from our and other groups have demonstrated that the majority of γ-aminobutyric acid (GABA)(A) receptor subunit mutations produce mutant subunits with impaired biogenesis and trafficking. These GABA(A) receptor mutations include missense, nonsense, deletion, or insertion mutations t...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3762703/ https://ncbi.nlm.nih.gov/pubmed/23216579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.12035 |
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