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Cytoplasmic dynein crosslinks and slides anti-parallel microtubules using its two motor domains

Cytoplasmic dynein is the predominant minus-end-directed microtubule (MT) motor in most eukaryotic cells. In addition to transporting vesicular cargos, dynein helps to organize MTs within MT networks such as mitotic spindles. How dynein performs such non-canonical functions is unknown. Here we demon...

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Bibliografische gegevens
Hoofdauteurs: Tanenbaum, Marvin E, Vale, Ronald D, McKenney, Richard J
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2013
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3762337/
https://ncbi.nlm.nih.gov/pubmed/24015359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00943
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