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Why Do More Divergent Sequences Produce Smaller Nonsynonymous/Synonymous Rate Ratios in Pairwise Sequence Comparisons?

Several studies have reported a negative correlation between estimates of the nonsynonymous to synonymous rate ratio (ω = d(N)/d(S)) and the sequence distance d in pairwise comparisons of the same gene from different species. That is, more divergent sequences produce smaller estimates of ω. Explanat...

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Detalhes bibliográficos
Main Authors: dos Reis, Mario, Yang, Ziheng
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761301/
https://ncbi.nlm.nih.gov/pubmed/23792953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.113.152025
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