Characterization of the Structural and Functional Determinants of MANF/CDNF in Drosophila In Vivo Model

Mammalian MANF and CDNF proteins are evolutionarily conserved neurotrophic factors that can protect and repair mammalian dopaminergic neurons in vivo. In Drosophila, the sole MANF protein (DmManf) is needed for the maintenance of dopaminergic neurites and dopamine levels. Although both secreted and...

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Hlavní autoři: Lindström, Riitta, Lindholm, Päivi, Kallijärvi, Jukka, Yu, Li-ying, Piepponen, T. Petteri, Arumäe, Urmas, Saarma, Mart, Heino, Tapio I.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3760817/
https://ncbi.nlm.nih.gov/pubmed/24019940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073928
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