Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) Has a Unique Mechanism to Rescue Apoptotic Neurons

Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects neurons and repairs the Parkinson disease-like symptoms in a rat 6-hydroxydopamine model. We show a three-dimensional solution structure of human MANF that differs drastically from other neurotrophic factors. Remarkably, the C-termi...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Hellman, Maarit, Arumäe, Urmas, Yu, Li-ying, Lindholm, Päivi, Peränen, Johan, Saarma, Mart, Permi, Perttu
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2011
Aiheet:
Protein Structure and Folding
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024763/
https://ncbi.nlm.nih.gov/pubmed/21047780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.146738
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