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Characterization of the Structural and Functional Determinants of MANF/CDNF in Drosophila In Vivo Model

Mammalian MANF and CDNF proteins are evolutionarily conserved neurotrophic factors that can protect and repair mammalian dopaminergic neurons in vivo. In Drosophila, the sole MANF protein (DmManf) is needed for the maintenance of dopaminergic neurites and dopamine levels. Although both secreted and...

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Detalhes bibliográficos
Main Authors: Lindström, Riitta, Lindholm, Päivi, Kallijärvi, Jukka, Yu, Li-ying, Piepponen, T. Petteri, Arumäe, Urmas, Saarma, Mart, Heino, Tapio I.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3760817/
https://ncbi.nlm.nih.gov/pubmed/24019940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073928
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