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Reprogramming Adult Human Dermal Fibroblasts to Islet-Like Cells by Epigenetic Modification Coupled to Transcription Factor Modulation
In this article, we describe novel conditions for culture, expansion, and transdifferentiation of primary human dermal fibroblasts (hDFs) to induce expression of transcription factors (TFs) and hormones characteristic of the islets of Langerhans. We show that histones associated with the insulin gen...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Mary Ann Liebert, Inc.
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3760074/ https://ncbi.nlm.nih.gov/pubmed/23627894 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2013.0134 |
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