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Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells

Prolonged antibiotic treatment can lead to detrimental side effects in patients, including ototoxicity, nephrotoxicity, and tendinopathy, yet the mechanisms underlying the effects of antibiotics in mammalian systems remain unclear. It has been suggested that bactericidal antibiotics induce the forma...

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Main Authors: Kalghatgi, Sameer, Spina, Catherine S., Costello, James C., Liesa, Marc, Morones-Ramirez, J Ruben, Slomovic, Shimyn, Molina, Anthony, Shirihai, Orian S., Collins, James J.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3760005/
https://ncbi.nlm.nih.gov/pubmed/23825301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3006055
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