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Mesothelin overexpression promotes mesothelioma cell invasion and MMP-9 secretion in an orthotopic mouse model and in epithelioid pleural mesothelioma patients

PURPOSE: Mesothelin (MSLN) is a tumor-associated antigen, being investigated as a biomarker and therapeutic target in malignant pleural mesothelioma (MPM). The biological function of MSLN overexpression in MPM is unknown. We hypothesized that MSLN may promote tumor invasion in MPM, a tumor character...

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書誌詳細
主要な著者: Servais, Elliot L., Colovos, Christos, Rodriguez, Luis, Bograd, Adam J., Nitadori, Jun-ichi, Sima, Camelia, Rusch, Valerie W., Sadelain, Michel, Adusumilli, Prasad S.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759995/
https://ncbi.nlm.nih.gov/pubmed/22371455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-2614
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