DHODH modulates transcriptional elongation in the neural crest and melanoma

Melanoma is a tumor of transformed melanocytes, which are derived from the embryonic neural crest. It is unknown to what extent the programs regulating neural crest development interact with mutations in the BRAF oncogene, the gene most commonly mutated in human melanoma(1). We have utilized the zeb...

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Hlavní autoři: White, Richard Mark, Cech, Jennifer, Ratanasirintrawoot, Sutheera, Lin, Charles Y., Rahl, Peter B., Burke, Christopher J., Langdon, Erin, Tomlinson, Matthew L., Mosher, Jack, Kaufman, Charles, Chen, Frank, Long, Hannah K., Kramer, Martin, Datta, Sumon, Neuberg, Donna, Granter, Scott, Young, Richard A., Morrison, Sean, Wheeler, Grant N., Zon, Leonard I.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759979/
https://ncbi.nlm.nih.gov/pubmed/21430780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09882
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