DHODH modulates transcriptional elongation in the neural crest and melanoma

Melanoma is a tumor of transformed melanocytes, which are derived from the embryonic neural crest. It is unknown to what extent the programs regulating neural crest development interact with mutations in the BRAF oncogene, the gene most commonly mutated in human melanoma(1). We have utilized the zeb...

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Autores principales: White, Richard Mark, Cech, Jennifer, Ratanasirintrawoot, Sutheera, Lin, Charles Y., Rahl, Peter B., Burke, Christopher J., Langdon, Erin, Tomlinson, Matthew L., Mosher, Jack, Kaufman, Charles, Chen, Frank, Long, Hannah K., Kramer, Martin, Datta, Sumon, Neuberg, Donna, Granter, Scott, Young, Richard A., Morrison, Sean, Wheeler, Grant N., Zon, Leonard I.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759979/
https://ncbi.nlm.nih.gov/pubmed/21430780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09882
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