The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes

Castrate-Resistant Prostate Cancer (CRPC) is characterized by persistent androgen receptor-driven tumor growth in the apparent absence of systemic androgens. Current evidence suggests that CRPC cells can produce their own androgens from endogenous sterol precursors that act in an intracrine manner t...

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Hlavní autoři: Fredericks, William J., Sepulveda, Jorge, Lal, Priti, Tomaszewski, John E., Lin, Ming-Fong, McGarvey, Terry, Rauscher, Frank J, Malkowicz, S. Bruce
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2013
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759667/
https://ncbi.nlm.nih.gov/pubmed/23919967
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