The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes

Castrate-Resistant Prostate Cancer (CRPC) is characterized by persistent androgen receptor-driven tumor growth in the apparent absence of systemic androgens. Current evidence suggests that CRPC cells can produce their own androgens from endogenous sterol precursors that act in an intracrine manner t...

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Detalhes bibliográficos
Main Authors: Fredericks, William J., Sepulveda, Jorge, Lal, Priti, Tomaszewski, John E., Lin, Ming-Fong, McGarvey, Terry, Rauscher, Frank J, Malkowicz, S. Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2013
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759667/
https://ncbi.nlm.nih.gov/pubmed/23919967
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