The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes

Castrate-Resistant Prostate Cancer (CRPC) is characterized by persistent androgen receptor-driven tumor growth in the apparent absence of systemic androgens. Current evidence suggests that CRPC cells can produce their own androgens from endogenous sterol precursors that act in an intracrine manner t...

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Autors principals: Fredericks, William J., Sepulveda, Jorge, Lal, Priti, Tomaszewski, John E., Lin, Ming-Fong, McGarvey, Terry, Rauscher, Frank J, Malkowicz, S. Bruce
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2013
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759667/
https://ncbi.nlm.nih.gov/pubmed/23919967
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