Proteasome Inhibition Promotes Parkin-Ubc13 Interaction and Lysine 63-Linked Ubiquitination

Disruption of the ubiquitin-proteasome system, which normally identifies and degrades unwanted intracellular proteins, is thought to underlie neurodegeneration. Supporting this, mutations of Parkin, a ubiquitin ligase, are associated with autosomal recessive parkinsonism. Remarkably, Parkin can prot...

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Main Authors: Lim, Grace G. Y., Chew, Katherine C. M., Ng, Xiao-Hui, Henry-Basil, Adeline, Sim, Roy W. X., Tan, Jeanne M. M., Chai, Chou, Lim, Kah-Leong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759450/
https://ncbi.nlm.nih.gov/pubmed/24023840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073235
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