Parkin Mediates Nonclassical, Proteasomal-Independent Ubiquitination of Synphilin-1: Implications for Lewy Body Formation

It is widely accepted that the familial Parkinson's disease (PD)-linked gene product, parkin, functions as a ubiquitin ligase involved in protein turnover via the ubiquitin-proteasome system. Substrates ubiquitinated by parkin are hence thought to be destined for proteasomal degradation. Becaus...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Lim, Kah Leong, Chew, Katherine C. M., Tan, Jeanne M. M., Wang, Cheng, Chung, Kenny K. K., Zhang, Yi, Tanaka, Yuji, Smith, Wanli, Engelender, Simone, Ross, Christopher A., Dawson, Valina L., Dawson, Ted M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2005
Assuntos:
Neurobiology of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726069/
https://ncbi.nlm.nih.gov/pubmed/15728840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4474-04.2005
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