Optimization of diarylazines as anti-HIV agents with dramatically enhanced solubility

Non-nucleoside inhibitors of HIV-1 reverse transcriptase are reported that have ca. 100-fold greater solubility than the structurally related drugs etravirine and rilpivirine, while retaining high anti-viral activity. The solubility enhancements come from strategic placement of a morpholinylalkoxy s...

Full description

Saved in:
Bibliographic Details
Main Authors: Bollini, Mariela, Cisneros, José A., Spasov, Krasimir A., Anderson, Karen S., Jorgensen, William L.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759246/
https://ncbi.nlm.nih.gov/pubmed/23937980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.06.091
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items