Optimization of diarylazines as anti-HIV agents with dramatically enhanced solubility

Non-nucleoside inhibitors of HIV-1 reverse transcriptase are reported that have ca. 100-fold greater solubility than the structurally related drugs etravirine and rilpivirine, while retaining high anti-viral activity. The solubility enhancements come from strategic placement of a morpholinylalkoxy s...

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Hlavní autoři: Bollini, Mariela, Cisneros, José A., Spasov, Krasimir A., Anderson, Karen S., Jorgensen, William L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759246/
https://ncbi.nlm.nih.gov/pubmed/23937980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.06.091
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