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p53 increases MHC class I expression by upregulating the endoplasmic reticulum aminopeptidase ERAP1

The p53 tumour suppressor has an important role in cancer cells. Here we show that p53 regulates expression of major histocompatibility complex I on the cell surface. We show that the tumour cell line HCT116, which lacks p53 exhibits significantly lower major histocompatibility complex I expression...

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Hlavní autoři: Wang, Bei, Niu, Dandan, Lai, Liyun, Ren, Ee Chee
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Pub. Group 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759077/
https://ncbi.nlm.nih.gov/pubmed/23965983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3359
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