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High-Throughput Luciferase Reporter Assay for Small-Molecule Inhibitors of MicroRNA Function

MicroRNAs (miRNAs) are endogenous, single-stranded, noncoding RNAs of 21 to 23 nucleotides that regulate gene expression, typically by binding the 3′ untranslated regions of target messenger RNAs. It is estimated that miRNAs are involved in the regulation of 30% of all genes and almost every genetic...

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Hlavní autoři: Connelly, Colleen M., Thomas, Meryl, Deiters, Alexander
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3758890/
https://ncbi.nlm.nih.gov/pubmed/22412086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057112439606
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