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Targeting a Regulatory Element in Human Thymidylate Synthase mRNA
Thymidylate synthase (TS) is a key enzyme in the biosynthesis of thymidine. TS inhibitors, which are used in cancer chemotherapy, suffer from resistance development in tumors through upregulation of TS expression. Autoregulatory translation control has been implicated with TS overexpression. TS bind...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3758747/ https://ncbi.nlm.nih.gov/pubmed/23143777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201200603 |
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