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Targeting a Regulatory Element in Human Thymidylate Synthase mRNA

Thymidylate synthase (TS) is a key enzyme in the biosynthesis of thymidine. TS inhibitors, which are used in cancer chemotherapy, suffer from resistance development in tumors through upregulation of TS expression. Autoregulatory translation control has been implicated with TS overexpression. TS bind...

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Bibliografiska uppgifter
Huvudupphovsmän: Brunn, Nicholas D., Sega, Emily Garcia, Kao, Melody B., Hermann, Thomas
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3758747/
https://ncbi.nlm.nih.gov/pubmed/23143777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201200603
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