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Structure of an RNA dimer of a regulatory element from human thymidylate synthase mRNA

A sequence around the start codon of the mRNA of human thymidylate synthase (TS) folds into a secondary-structure motif in which the initiation site is sequestered in a metastable hairpin. Binding of the protein to its own mRNA at the hairpin prevents the production of TS through a translation-repre...

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Autors principals: Dibrov, Sergey, McLean, Jaime, Hermann, Thomas
Format: Artigo
Idioma:Inglês
Publicat: International Union of Crystallography 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3045271/
https://ncbi.nlm.nih.gov/pubmed/21245530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444910050900
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