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Expression, purification and crystallization of the ancestral androgen receptor–DHT complex

Steroid receptors (SRs) are a closely related family of ligand-dependent nuclear receptors that mediate the transcription of genes critical for development, reproduction and immunity. SR dysregulation has been implicated in cancer, inflammatory diseases and metabolic disorders. SRs bind their cognat...

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Hlavní autoři: Colucci, Jennifer K., Ortlund, Eric A.
Médium: Artigo
Jazyk:Inglês
Vydáno: International Union of Crystallography 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3758146/
https://ncbi.nlm.nih.gov/pubmed/23989146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309113018745
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