Targeted estrogen delivery reverses the metabolic syndrome

We report the development of a new combinatorial approach that allows for peptide-mediated selective tissue targeting of nuclear hormone pharmacology while eliminating adverse effects in other tissues. Specifically, we report the development of a glucagon-like peptide-1 (GLP-1)-estrogen conjugate th...

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Hauptverfasser: Finan, Brian, Yang, Bin, Ottaway, Nickki, Stemmer, Kerstin, Müller, Timo D, Yi, Chun-Xia, Habegger, Kirk, Schriever, Sonja C, García-Cáceres, Cristina, Kabra, Dhiraj G, Hembree, Jazzminn, Holland, Jenna, Raver, Christine, Seeley, Randy J, Hans, Wolfgang, Irmler, Martin, Beckers, Johannes, de Angelis, Martin Hrabě, Tiano, Joseph P, Mauvais-Jarvis, Franck, Perez-Tilve, Diego, Pfluger, Paul, Zhang, Lianshan, Gelfanov, Vasily, DiMarchi, Richard D, Tschöp, Matthias H
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757949/
https://ncbi.nlm.nih.gov/pubmed/23142820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3009
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