The human lipodystrophy protein seipin is an ER membrane adaptor for the adipogenic PA phosphatase lipin 1

Disruption of the gene BSCL2 causes a severe, generalised lipodystrophy, demonstrating the critical role of its protein product, seipin, in human adipose tissue development. Seipin is essential for adipocyte differentiation, whilst the study of seipin in non-adipose cells has suggested a role in lip...

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Autors principals: Sim, M.F. Michelle, Dennis, Rowena J., Aubry, Evelyne M., Ramanathan, Nardev, Sembongi, Hiroshi, Saudek, Vladimir, Ito, Daisuke, O'Rahilly, Stephen, Siniossoglou, Symeon, Rochford, Justin J.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2012
Matèries:
Brief Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757660/
https://ncbi.nlm.nih.gov/pubmed/24024128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2012.11.002
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