Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis

OBJECTIVE: Disruption of the genes encoding either seipin or 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2) causes severe congenital generalized lipodystrophy (CGL) in humans. However, the function of seipin in adipogenesis remains poorly defined. We demonstrated recently that seipin can bi...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Talukder, Md. Mesbah Uddin, Sim, M.F. Michelle, O'Rahilly, Stephen, Edwardson, J. Michael, Rochford, Justin J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338318/
https://ncbi.nlm.nih.gov/pubmed/25737955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2014.12.013
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