Eukaryote-Specific Insertion Elements Control Human ARGONAUTE Slicer Activity

We solved the crystal structure of human ARGONAUTE1 (hAGO1) bound to endogenous 5′-phosphorylated guide RNAs. To identify changes that evolutionarily rendered hAGO1 inactive, we compared our structure with guide-RNA-containing and cleavage-active hAGO2. Aside from mutation of a catalytic tetrad resi...

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Main Authors: Nakanishi, Kotaro, Ascano, Manuel, Gogakos, Tasos, Ishibe-Murakami, Satoko, Serganov, Artem A., Briskin, Daniel, Morozov, Pavel, Tuschl, Thomas, Patel, Dinshaw J.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757560/
https://ncbi.nlm.nih.gov/pubmed/23809764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.06.010
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