IL-4 inhibition of IL-1 induced Matrix Metalloproteinase-3 (MMP-3) expression in human fibroblasts involves decreased AP-1 activation via negative crosstalk involving of Jun N-terminal Kinase (JNK)

Matrix metalloproteinase-3 (MMP-3) over-expression is associated with tissue destruction in the context of chronic inflammation. Previous studies showed that IL-4 inhibits induction of MMP-3 by IL-1β, and suggested that AP-1 might be involved. Here we show that IL-1 induced binding of transcription...

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Autores principales: Chambers, Mariah, Kirkpatrick, Garrett, Evans, Michel, Gorski, Grzegorz, Foster, Sara, Borghaei, Ruth C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757497/
https://ncbi.nlm.nih.gov/pubmed/23608488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2013.04.010
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