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GTP Is the Primary Activator of the Anti-HIV Restriction Factor SAMHD1
SAMHD1 (SAM domain- and HD domain-containing protein 1) is a dGTP-dependent dNTP triphosphohydrolase that converts dNTPs into deoxyribonucleosides and triphosphates. Therefore, SAMHD1 expression, particularly in non-dividing cells, can restrict retroviral infections such as HIV and simian immunodefi...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3757166/ https://ncbi.nlm.nih.gov/pubmed/23880768 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C113.493619 |
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