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GTP Is the Primary Activator of the Anti-HIV Restriction Factor SAMHD1

SAMHD1 (SAM domain- and HD domain-containing protein 1) is a dGTP-dependent dNTP triphosphohydrolase that converts dNTPs into deoxyribonucleosides and triphosphates. Therefore, SAMHD1 expression, particularly in non-dividing cells, can restrict retroviral infections such as HIV and simian immunodefi...

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Autores principales: Amie, Sarah M., Bambara, Robert A., Kim, Baek
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757166/
https://ncbi.nlm.nih.gov/pubmed/23880768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C113.493619
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